Nitoaldol reaction in aqueous media: an important improvement of the henry reaction

摘要

Carbon-carbon bond formation is the essence of or- ganic synthesis; the Henry reaction, an aldol-type reac- tion, represents one of the classical C-C bond-forming processes, and its variants have been used extensively in many important syntheses. The classical nitroaldol reaction is performed, as Routine procedure, in presence of a base (Scheme 1) in An organic solvent.