Palladium-Catalyzed Suzuki-Type Cross-Couplings of Iodocyclopropanes with Boronic Acids: Synthesis of trans-1,2-Dicyclopropyl Alkenes

摘要

We have reported the first cross-coupling reaction of substituted cyclopropyl iodides with boronic acids. This methodology represents the first insertion of palladium(0) in a cyclopropyl halide bond, and it opens the door to other palladium-catalyzed coupling reactions involving cyclopropyl iodides.