N-Acylazinium Salts: A New Source of Iminium Ions for Ugi-Type Processes

摘要

A multicomponent reaction involving the interaction of azines (quinolines, isoquinolines, and phenanthri-dine) with activating agents (chloroformates, acid halides, and sulfonyl halides), isocyanides, and water is described. The products of this process, α-carbamoylated-1,2-dihy-droazines, are the result of the addition of the isocyanide partner to the N-acylazinium salt formed in situ. This represents a new source of iminium ion equivalents for Ugi-type reactions.