Cud) Catalyst in DMF:An Efficient Catalytic System for the Synthesis of Furans from 2-(l-Alkynyl)-2-alken-l-ones

摘要

The cyclization of 2-(l-alkynyl)-2-alken-l-ones 1 proceeded very smoothly in the presence of alcohols 2 with a catalytic amount of Cu(I)Br in DMF at 80 deg C,leading to the formation of highly substituted furans 3.The catalytic system reported herein is easy to handle,compared to the previously known system wherein the reaction between 1 and 2 needed to use moisture sensitive gold(III) chloride.