Enantioselective Synthetic Method for α-Alkylserine via Phase-Transfer Catalytic Alkylation of 2-Phenyl-2-oxazoline-4- carbonylcamphorsultam

摘要

An enantioselective synthetic method for α-alkylserines by the phase-transfer catalytic alkylation of 2-phenyl-2-oxazo-line-4-carbonylcamphorsultam (4a) was developed. The phase-transfer catalytic α-alkylation of 4a using P2-Et at -78 ℃ gave 　α-alkylation (75～99%, 90～97% de), which could be easily hydrolyzed to α-alkylserines.