RCM-Mediated Synthesis of Trifluoromethyl-Containing Nitrogen Heterocycles

摘要

A ring-closing metathesis mediated pathway to trifluoromethyl-containing piperidines is detailed.This involves the development of a synthetic route to a new (trifluoromethyl)allylating reagent via a Diels- Alder/retro-Diels-Alder strategy,its application in the synthesis of a series of trifluormethyl-substituted diolefin precursors for ring-closing metathesis,and eventually the successful cyclization of these precursor molecules into the corresponding functionalized piperidines.