Synthesis of Two Unnatural Oxygenated Aaptaminoids

摘要

Two unprecedented oxygenated aaptaminoidsnhave been synthesized starting from cheap and easily availablen2,3-dihydroxybenzoic acid with the satisfactory overall yields ofn31% and 34%. The key step of the procedure is the divergentnthermic 5-exodig vs base-promoted 6-endodig cyclization of a 5-nalkynylquinolinone derivative.