Physiology of endothelin in producing myocardial perfusion heterogeneity: A mechanistic study using darusentan and positron emission tomography

摘要

Background Heterogeneity of resting perfusion may be due in part to up-regulation of coronary vasoconstriction via endothelin (ET) type A receptors, as homogeneity increases during subsequent vasodilatory hyperemia. Therefore, we conducted a mechanistic study using an ET receptor antagonist to determine if it could alter the homogeneity of myocardial perfusion.