首页> 外文期刊>Journal of Nanoparticle Research >Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle
【24h】

Enhancement of transport of curcumin to brain in mice by poly(n-butylcyanoacrylate) nanoparticle

机译:聚(氰基丙烯酸正丁酯)纳米颗粒增强姜黄素向小鼠脑内转运的作用

获取原文
获取原文并翻译 | 示例
       

摘要

Curcumin, a widely used coloring agent and spice in food, has a potential in blocking brain tumor formation and curing Alzheimer’s disease. Due to the specific properties of blood–brain barrier (BBB), only traces of curcumin were transported across BBB. The aim of the present study was to design and characterize curcumin loaded polybutylcyanoacrylate nanoparticles (PBCN) coated with polysorbate 80, and to evaluate the effect of PBCN as a delivery system on carrying curcumin across BBB. Curcumin loaded nanoparticles were prepared by an anionic polymerization method, and they presented in a core–shell spherical shape under transmission electron microscopy, with an average diameter of 152.0 nm. The average drug loading was 21.1%. Physicochemical status of curcumin in the nanoparticles was confirmed with differential scanning colorimetry and Fourier transform infrared spectroscopy. The in vitro release behavior of drug from the nanoparticles was fitted to a double phase kinetics model. The studies of pharmacokinetic and bio-distribution to brain were conducted in mice after intravenous administration of the nanoparticle formulation at the dose of 5 mg/kg and curcumin solution at the dose of 10 mg/kg via the tail vein. The results showed that in plasma, the area under concentration–time curve (AUC0–∞) for curcumin loaded nanoparticles was greater than that for the control solution, moreover, the mean residence time of curcumin loaded nanoparticles was 14-fold that of the control solution. In brain, AUC0–∞ for curcumin loaded nanoparticles was 2.53-fold that for the control solution. In conclusion, the present study demonstrated that PBCN could enhance the transport of curcumin to brain and have a potential as a delivery system to cross the BBB.
机译:姜黄素是食品中广泛使用的着色剂和香料,具有阻止脑瘤形成和治愈阿尔茨海默氏病的潜力。由于血脑屏障(BBB)的特殊性质,仅姜黄素的痕迹跨过BBB转运。本研究的目的是设计和表征涂有聚山梨酯80的姜黄素负载的聚氰基丙烯酸丁酯纳米颗粒(PBCN),并评估PBCN作为递送系统对姜黄素跨BBB的影响。载有姜黄素的纳米颗粒是通过阴离子聚合法制备的,在透射电子显微镜下呈核-壳球形,平均直径为152.0 nm。平均载药量为21.1%。通过差示扫描比色法和傅里叶变换红外光谱法确认了姜黄素在纳米颗粒中的理化状态。将药物从纳米颗粒的体外释放行为拟合至双相动力学模型。在经由尾静脉静脉内施用剂量为5mg / kg的纳米颗粒制剂和剂量为10mg / kg的姜黄素溶液之后,在小鼠中进行了对脑的药代动力学和生物分布的研究。结果表明,在血浆中,姜黄素负载的纳米颗粒在浓度-时间曲线下的面积(AUC 0-∞)大于对照溶液,此外,姜黄素负载的纳米颗粒的平均停留时间是对照溶液的14倍。在大脑中,载有姜黄素的纳米颗粒的AUC 0–∞ 是对照溶液的AUC 0–∞ 。总之,本研究表明,PBCN可以增强姜黄素向大脑的转运,并具有作为穿越BBB的传递系统的潜力。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱:kefu@zhangqiaokeyan.com

京公网安备:11010802029741号 ICP备案号:京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有
  • 客服微信

  • 服务号