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Changes of apoptosis in rats of acute ischemic renal injury under treatment of tetrandrine

机译:粉防己碱治疗急性缺血肾损伤大鼠细胞凋亡的变化。

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Conclusion Tetrandrine could adjust he level of apoptosis in renal tubular epithelium and alleviate renal tissular injury. Objective to elucidate the effect of tetrandrine on acute ischemic renal injury And its relation with apoptosis. Methods A model for bilateral post-ischemic renal injury in rats Was developed by clamping renal pedicles of 45 min. renal tissular DNA fragmentation analysis And renal tissular HE staining were used. Also quantitative analysis of apoptosis in injured renal Tubular epithelium was carried out by using TdT-mediated dUTP nick and labeling(TUNEL).
机译:结论粉防己碱可调节肾小管上皮细胞凋亡水平,减轻肾组织损伤。目的阐明粉防己碱对急性缺血性肾损伤的作用及其与细胞凋亡的关系。方法通过夹闭肾蒂45分钟建立大鼠双侧缺血性肾损伤模型。肾组织DNA片段分析和肾组织HE染色。还使用TdT介导的dUTP缺口和标记(TUNEL)对受伤的肾小管上皮细胞凋亡进行了定量分析。

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