Association of Glu298Asp Polymorphism of the Endothelial Nitric Oxide Synthase Gene with Essential Hypertension in Elderly People

摘要

Objective: To investigate the association of Glu298Asp polymorphism of the eNOS gene with essential hypertension in elderly people. Methods: Ninety-five cases of essential hypertension were randomly chosen from outpatients and inpatients as the study group, and an equal number of sexes, age-matched healthy people as the control group. Their height, weight and blood pressure were recorded and their fasting plasma lipid concentrations were measured. Glu298Asp polymorphism of the eNOS gene was measured using the methods of PCR and RFLP. Results: The constituent ratio of Genotype Glu/Asp in the study group (26.3%) was higher than that in the control group (12.6%, x~2 = 5. 67, P<0.05), the allelic frequency of 298Asp in the study group (13.2%) was significantly higher than that in the control group (6.3%, x~2 = 5.06, P<0.05). Conclusion: Glu298 Asp variant of the eNOS gene may be an independent predictor in essential hypertension.