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首页> 外文期刊>Journal of Nanjing Medical University >The role of nerve growth factor inducible protein B in the pathogenesis of levodopa-induced dyskinesias
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The role of nerve growth factor inducible protein B in the pathogenesis of levodopa-induced dyskinesias

机译:神经生长因子诱导蛋白B在左旋多巴诱发的运动障碍发病机理中的作用

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摘要

Objective: To study the role of the expression of nerve growth factor inducible protein B gene (NGFI-B) in stria-tum in the pathogenesis of levodopa-induced dyskinesias (LID). Methods: The rat model of LID was treated with SCH 23390(1 mg/kg ip,a dopamine D1 antagonist) and haloperidol (1 mg/kg ip,a dopamine D2 antagonist) respectively. Reverse transcriptase-polymerase chain reaction (RT-PCR) was used to measure the expression of NGFI-B mRNA in striatum and the behavior changes were observed. Results: After treatment with SCH23390, abnormal involuntary movement (AIM) in LID rats was decreased (P < 0.05) and the expression of NGFI-B mRNA in striatum did not change significantly. After treatment with haloperidol, the changes of AIM in LID rats were not significant and the expression of NGFI-B mRNA was increased significantly( P < 0.01). Conclusion: LID is associated with over-expression of NGFI-B in striatum. Abnormal activity in the direct pathway and the basal ganglia circuit could be involved in the occurrence of LID.
机译:目的:研究纹状体中神经生长因子诱导蛋白B基因(NGFI-B)的表达在左旋多巴诱发的运动障碍(LID)发病中的作用。方法:分别用SCH 23390(1 mg / kg ip,多巴胺D1拮抗剂)和氟哌啶醇(1 mg / kg ip,多巴胺D2拮抗剂)治疗LID大鼠模型。用逆转录-聚合酶链反应(RT-PCR)检测纹状体中NGFI-B mRNA的表达,观察其行为变化。结果:用SCH23390治疗后,LID大鼠的非自愿运动(AIM)减少了(P <0.05),纹状体中NGFI-B mRNA的表达没有明显改变。氟哌啶醇治疗后,LID大鼠AIM变化不明显,NGFI-B mRNA表达明显升高(P <0.01)。结论:LID与纹状体中NGFI-B的过度表达有关。 LID的发生可能与直接途径和基底神经节回路的异常活动有关。

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