Skeletal muscle fibre type specification during embryonic development

摘要

In the last 10 years an increasing number of studies have provided an insight in the signalling mechanisms underlying myogenesis and fibre type specification during embryonic development: this paper aims to review the most relevant findings. In vertebrates a central role in muscle differentiation is played by the MyoD family, a group of transcription factors which activate transcription of muscle specific genes. In turn MyoD family is expressed in response to inductive signals coming from tissues adjacent to somites, in the first place the notochord and the neural tube. Hedgehog and Wnt are among these inductive signals and they find in the future myoblasts a response pathway which includes Ptc, Smu and Gli. The signalling mechanisms have been analysed in model organisms: mouse, chick, zebrafish and Drosophila. For some factors the orthologs in different species have been found to accomplish similar function, but for some other factors important differences are present: for example in Drosophila twist codes for a transcription factor which promotes myogenesis, whereas its ortholog in mouse tends to prevent or inhibit myogenesis. Conversely, nautilus which is the orholog of MyoD in Drosophila does not have a general function in muscle differentiation, but is required for the differentiation of a limited group of muscle fibres.