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首页> 外文期刊>Journal of Medicinal Food >Medicinal Values of Fruit Peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with Respect to Alterations in Tissue Lipid Peroxidation and Serum Concentration of Glucose, Insulin, and Thyroid Hormones
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Medicinal Values of Fruit Peels from Citrus sinensis, Punica granatum, and Musa paradisiaca with Respect to Alterations in Tissue Lipid Peroxidation and Serum Concentration of Glucose, Insulin, and Thyroid Hormones

机译:柑桔,石榴和石榴的果皮对组织脂质过氧化和葡萄糖,胰岛素和甲状腺激素的浓度变化的药用价值

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Peel extracts from Citrus sinensis, Punica granatum, and Musa paradisiaca were investigated for their effects on tissue lipid peroxidation (LPO) and on the concentration of thyroid hormones, insulin, and glucose in male rats. In vitro inhibition of H2O2-induced LPO in red blood cells of rats by 0.25, 0.50, 1.0, and 2.0 μg/mL C. sinensis, P. granatum, and M. paradisiaca peel extracts was observed in a dose-specific manner. Maximum inhibition was observed at 0.50 μg/mL C. sinensis, 2.0 μg/mL P. granatum, and 1.0 μg/mL M. paradisiaca. In the in vivo investigation, out of four different concentrations of each peel extract, 25, 200, and 100 mg/kg C. sinensis, P. granatum, and M. paradisiaca, respectively, were found to maximally inhibit hepatic LPO. The most effective doses were further evaluated for effects on serum triiodothyronine (T3), thyroxine (T4), insulin, and glucose concentrations. C. sinensis exhibited antithyroidal, hypoglycemic, and insulin stimulatory activities, in addition to inhibition of LPO, as it significantly decreased the serum T4 (P < .05) and glucose (P < .001) concentrations with a concomitant increase in insulin levels (P < .05). P. granatum decreased LPO in hepatic, cardiac, and renal tissues (P < .01, P < .001, and P < .05, respectively) and serum glucose concentration (P < .01). M. paradisiaca strongly inhibited the serum level of thyroid hormones (P < .01 for both T3 and T4) but increased the level of glucose (P < .05). These findings reveal the hitherto unknown potential of the tested peel extracts in the regulation of thyroid function and glucose metabolism. Besides antiperoxidative activity, C. sinensis extract has antithyroidal, hypoglycemic, and insulin stimulatory properties, which suggest its potential to ameliorate both hyperthyroidism and diabetes mellitus.
机译:研究了柑桔,石榴和石榴的皮提取物对雄性大鼠组织脂质过氧化(LPO)以及甲状腺激素,胰岛素和葡萄糖浓度的影响。 0.25、0.50、1.0和2.0μg/ mL中华按蚊,体育颗粒和天堂果皮提取物对H2O2诱导的LPO在大鼠红细胞中的体外抑制作用具有剂量特异性。在0.50μg/ mL中华假丝酵母,2.0μg/ mL颗粒状假单胞菌和1.0μg/ mL天堂实蝇中观察到最大抑制作用。在体内研究中,在每种果皮提取物的四种不同浓度中,分别发现25、200和100 mg / kg中华C,颗粒状青霉和天堂莫拉氏菌最大程度地抑制了肝LPO。进一步评估了最有效剂量对血清三碘甲状腺素(T3),甲状腺素(T4),胰岛素和葡萄糖浓度的影响。除抑制LPO外,中华绒螯蟹还表现出抗甲状腺,降血糖和胰岛素刺激的作用,因为它显着降低了血清T4(P <.05)和葡萄糖(P <.001)的浓度,同时胰岛素水平也随之升高( P <.05)。颗粒状假单胞菌降低了肝,心脏和肾组织的LPO(分别为P <.01,P <.001和P <.05)和血清葡萄糖浓度(P <.01)。天堂分枝杆菌强烈抑制甲状腺激素的血清水平(T3和T4的P <0.01),但葡萄糖水平升高(P <.05)。这些发现揭示了被测果皮提取物在调节甲状腺功能和葡萄糖代谢方面迄今未知的潜力。除抗过氧化活性外,中华茶提取物还具有抗甲状腺,降血糖和胰岛素刺激的特性,这表明其具有改善甲状腺功能亢进症和糖尿病的潜力。

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