Role of microsatellite instability in occurrence of colorectal carcinoma and its prognostic significance

Yan Xiaochu; Chen Yisheng; Liu Fengxuan

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Role of microsatellite instability in occurrence of colorectal carcinoma and its prognostic significance

机译：微卫星不稳定性在结直肠癌发生中的作用及其预后意义

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Objective: to explore the role of microsatellit einstability (MSI) in the occurrence of colorectal carcinoma and the relationship between MSI and prognosis of the carcinoma. Methods: MSI at 6 loci of D18S34, D17S799, D5S409, TCF-2, P53 and Rb in 56 cases of colorectal carcinoma were detected with PRCR- SSLP. Results: The total positive rate of MSI was 44.64/100. The 3- or 5-year survival rate was higher in the Cases with MSI than in those without.

机译：目的：探讨微卫星不稳定性（MSI）在结直肠癌发生中的作用以及MSI与癌预后的关系。方法：用PRCR-SSLP检测56例大肠癌中D18S34，D17S799，D5S409，TCF-2，P53和Rb 6个位点的MSI。结果：MSI总阳性率为44.64 / 100。有MSI的病例的3或5年生存率高于没有MSI的病例。

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《Journal of Medical Colleges of PLA》 |1999年第2期|p.134-137|共4页
作者
Yan Xiaochu; Chen Yisheng; Liu Fengxuan;
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原文格式 PDF
正文语种 eng
中图分类医药、卫生;
关键词
colorectal carcinoma; microsatellite instability; prognosis;

机译：大肠癌;微卫星不稳定性;预后;

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专利

1. Role of microsatellite instability in occurrence of colorectal carcinoma and its prognostic significance [J] . 阎晓初, 陈意生, 柳凤轩, 中国人民解放军军医大学学报：英文版 . 1999,第002期

机译：微卫星不稳定性在结直肠癌发生中的作用及其预后意义
2. Genomic instability measured by inter-(Simple Sequence Repeat) PCR and high-resolution microsatellite instability are prognostic of colorectal carcinoma survival after surgical resection [J] . BrennerB.M., SwedeH., JonesB.A., Annals of surgical oncology . 2012,第1期

机译：通过（简单序列重复）PCR测量的基因组不稳定性和高分辨率微卫星不稳定性是手术切除后结直肠癌存活的预后
3. Genomic Instability Measured by Inter-(Simple Sequence Repeat) PCR and High-Resolution Microsatellite Instability are Prognostic of Colorectal Carcinoma Survival After Surgical Resection [J] . Annals of Surgical Oncology . 2012,第1期

机译：通过（简单重复序列）PCR和高分辨率微卫星不稳定性测量的基因组不稳定性是手术切除后结直肠癌生存的预后。
4. Prognostic Factors for the Presence of the Methastasis in Lymph Nodes and Organs in Bulgarien Patients with Colorectal Carcinoma [C] . Nedyalka Zgurova, Krasimira Prodanova, Maria Tzaneva, International Conference on Applications of Mathematics in Engineering and Economics . 2018

机译：预后因子在保加利亚患者淋巴结患者淋巴结和器官中的存在性导致结直肠癌患者
5. Mutation profiling in colorectal cancer patients with microsatellite instability; High frequency of BRCA2 and EGFR somatic mutations [D] . Deihimi, Safoora. 2016

机译：具有微卫星不稳定性的大肠癌患者的突变谱； BRCA2和EGFR体细胞突变的频率高
6. Genomic Instability Measured by Inter-(Simple Sequence Repeat) PCR and High-Resolution Microsatellite Instability are Prognostic of Colorectal Carcinoma Survival After Surgical Resection [O] . Bruce M. Brenner, Helen Swede, Beth A. Jones, -1

机译：通过跨（简单重复序列）pCR和高分辨率微卫星不稳定性测定基因组不稳定性是大肠癌生存的预后在手术切除后
7. Genomic Instability Measured by Inter-(Simple Sequence Repeat) PCR and High-Resolution Microsatellite Instability are Prognostic of Colorectal Carcinoma Survival After Surgical Resection [O] . Brenner, Bruce M., Swede, Helen 2012

机译：通过（简单重复序列）PCR和高分辨率微卫星不稳定性测量的基因组不稳定性是手术切除后结直肠癌生存的预后。

Role of microsatellite instability in occurrence of colorectal carcinoma and its prognostic significance

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