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Evolution of the ancestral recombination graph along the genome in case of selective sweep

机译:选择性扫描情况下祖先重组图沿基因组的演变

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摘要

We consider the genome of a sample of n individuals taken at the end of a selective sweep, which is the fixation of an advantageous allele in the population. When the selective advantage is high, the genealogy at a locus under selective sweep can be approximated by a comb with n teeth. However, because of recombinations during the selective sweep, the hitchhiking effect decreases as the distance from the selected site increases, so that far from this locus, the tree can be approximated by a Kingman coalescent tree, as in the neutral case. We first give the distribution of the tree at a given locus. Then we focus on the evolution of this tree along the genome. Since this tree-valued process is not Markovian, we study the evolution of the Ancestral Recombination Graph along the genome in case of selective sweep.
机译:我们考虑在选择性扫描结束时采集的n个个体的样本的基因组,这是种群中有利等位基因的固定。当选择优势高时,可以通过带有n齿的梳子来近似选择扫描下某个位置的家谱。但是,由于选择性扫描期间的重组,搭便车的效果会随着与选定位置的距离增加而降低,因此,与中性情况相比,该树可以由Kingman合并树进行近似,从而远离该位置。我们首先给出给定位置的树的分布。然后,我们重点研究这棵树沿着基因组的进化。由于此树值过程不是马尔可夫模型,因此在选择性扫描的情况下,我们研究了祖先重组图沿基因组的演化。

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