Novel models of magnetic dynamics for characterization of nanoparticles biodegradation in a body from Mossbauer and magnetization measurements

摘要

We discuss ways of an improvement of the analytic technique for characterization of magnetic nanoparticles and their chemical transformation to ferritin-like forms after their injection in a living organism by means of measuring and analyzing the Mossbauer spectra and magnetization curves. This is based first on the theoretical achievements in developing models of magnetic dynamics of antiferromagnetic nanoparticles for describing thermodynamic properties of ferritin and related proteins. Generalization of the approach for ferrimagnetic nanoparticles allows one to take directly into account the magnetic nature of nanoparticles in analyzing the corresponding experimental data. Another way is to extend this technique with measuring and analyzing non-equilibrium magnetization curves (hysteresis loops) which allows one to more reliably evaluate time changes in the residual nanoparticles and iron-containing proteins characteristics during biodegradation. (C) 2017 Elsevier B.V. All rights reserved.