平成23年度前期国際研究集会派遣会員報告書

摘要

第19回国際磁気共鳴医学会ISMRM2011が，5月7日（土）～13日（金）カナダのMontrealにて開催された．今回私は0由1で1演題，traditional posterで1演題，共同研究の共著としてE-podterで1演題，合計3演題の採択をいただいき参加させていただいたので報告する．%Recent studies on the utility of manganese have shown that manganese-enhanced MRI (MEMRI) can detect cellular alterations in tumor models. In addition, the intercellular contrast agent MnCl_2 has been successfully used to assess cell viability in heart ischemia, and cells can be easily labeled using Mn~(2+) in vitro. Hasegawa et al. reported that MEMRI can reflect MnSOD over-expression in a tumor model2'. Radiotherapy using high-energy X-rays treats malignancies with the intention of destroying or inactivating cells while preserving normal tissue integrity. We investigated the relationship between X-ray irradiation and Mn uptake in tumor cells and tested whether MEMRI can detect radiation-induced cell disturbances at an early stage both in vitro and in vivo.