Synthesis, Characterization and Kinetic Release Profile of Iron Containing Polymeric Co-conjugates with Antiproliferative Activity

摘要

In this research, the incorporation or rerrocen-ecarboxyaldehyde, 3-ferrocenylprop-2-enal and acetylfer-rocene to a polymeric backbone via hydrazone bond to form conjugates and co-conjugates was demonstrated. The conjugates and co-conjugates containing bioactive agents were characterized by nuclear magnetic resonance spec-troscopy, Fourier transform spectroscopy and UV-visible Spectroscopy. Kinetic release studies of 3-ferrocenylprop-2-enal and acetylferrocene from the polymeric carriers was performed using various mathematical release models. The mechanism of release of ferrocenylpropenal and acetylferrocene followed Korsmeyer-Peppas release profile with a diffusion coefficient of n ＞ 5 at selected pH values indicating anomalous (non-Fickian) diffusion.