Inspired by the string landscape and the unified gauge coupling relation in the F-theory Grand Unified Theories (GUTs) and GUTs with suitable high-dimensional operators, we study the canonical gauge coupling unification and Higgs boson mass in the Standard Model (SM) with high-scale supersymmetry breaking. In the SM with GUT-scale supersymmetry breaking, we achieve the gauge coupling unification at about 5.3 × 1013 GeV, and the Higgs boson mass is predicted to range from 130 GeV to 147 GeV. In the SM with supersymmetry breaking scale from 104 GeV to 5.3 × 1013 GeV, gauge coupling unification can always be realized and the corresponding GUT scale M U is from 1016 GeV to 5.3 × 1013 GeV, respectively. Also, we obtain the Higgs boson mass from 114.4 GeV to 147 GeV. Moreover, the discrepancies among the SM gauge couplings at the GUT scale are less than about 4-6%. Furthermore, we present the SU(5) and SO(10) models from the F-theory model building and orbifold constructions, and show that we do not have the dimension-five and dimension-six proton decay problems even if M U ≤ 5 × 1015 GeV.
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