Nutraceutical extracts from some endemic Onosma (O. circinnata, O. bornmuelleri, and O. angustissima) species: LC–ESI-MS/MS–based polyphenol profile, antioxidant and enzyme inhibition activities

摘要

This study aimed to determine the chemical composition of methanol extracts from Onosma circinnata, Onosma bornmuelleri, and Onosma angustissima and to investigate their antioxidant and enzyme inhibitory activities. Spectrophotometric analysis showed that the extracts were found to be rich in chlorogenic acid, luteolin 7-glucoside, rosmarinic acid, and apigenin 7-glucoside. While O. bornmuelleri showed the highest activity in DPPH, ABTS, and FRAP tests, O. circinnata was more effective in CUPRAC, phosphomolybdenum, and ferrous ion chelating tests. While O. angustissima showed significant inhibitory activities on AChE, BChE, and tyrosinase, O. bornmuelleri and O. circinnata showed the highest inhibitory activities on α-amylase and α-glucosidase. It was concluded that O. circinnata and O. bornmuelleri are effective antioxidant agents and O. angustissima can be considered as an alternative agent in the medical and cosmetic industries due to its ChE and tyrosinase inhibitory activities.