The effects of metal ion contaminants on the double stranded DNA helix and diseases

摘要

Mineral metal ions are essential for the maintenance of the reactions that regulate homeostasis and the functions of our body. It is known that the regulation of the neurodegenerative system depends directly on life metal ions, such as Na, K, Mg, Ca, Fe, Mo, Cu, Co, Zn, Cr, Mn, while the toxic metals Cd, Pb, Hg, etc disturb homeostasis, leading to diseases. Particularly significant is the effect of toxic metals on the double stranded forms of DNA and conformations. It was found that the toxic metal ions by reacting specifically with the nucleic bases and electrostatically with the negatively phosphate groups of the DNA backbone cause changes in the structure of the DNA double helix, leading to breaks of single or double strands. Accumulation of these defects affects the protecting systems of the body and induces mutations, eventually leading to serious diseases. There are many metal ions, such as Cr, Al, Cd, Cu, Ni, which by binding directly to DNA molecule or by developing oxidative stress increase the instability of DNA, promoting epigenetic changes that lead to DNA damage. Toxic metal ions induce indirect DNA damage and influence the gene stability by inactivating encoding proteins or by changing the redox potential and the signaling of metalloenzymes.