Barrier Repair After Tape Stripping: Effects of Semi-Permeable Membranes on the Natural Moisturizing Factor of the Skin (NMF)

摘要

Semi-permeable wound dressings facilitate skin barrier recovery for superficial wounds, e.g., tape stripping Varying humidity levels, such as those produced by semi-permeable dressings, are known to influence conversion of filaggrin into NMF(1). This study examined the relationship between these two known issues in skin health. The skin barrier was damaged in a controlled fashion by tape stripping to four times the baseline TEWL. The skin barrier recovery under varying humidity created by membranes of varying permeabilities was measured by biophysical methods (TEWL, rate of moisture accumulation [MAT], visual grading), as previously described (2). After 5 days ,skin surface samples were collected (D-Squames~R) from all test sites for measurement of NMF levels using our previously reported method(3).