GENETIC RESPONSE OF HUMAN ADIPOCYTES TO EXTERNAL STIMULI: HIGH SPECIFICITY AS REVEALED BY DETAILED UNA ARRAY ANALYSIS AND UPID STORAGE MODULATION IN A 3D HYPODERMIS MODELE

摘要

Given the fact that human adipocytes have not necessarily co-evolved with specific non-food plant molecules, it is surprising to see the high specificity of activity of two superficially similar structures on these cells. Although DNA array, data mining, in vitro enzymatic and proteomic studies and analysis of 3D hypodermis models allow us to understand in increasing detail the modulation of lipid storage in adipocytes, we still need to find the primary, intrinsic substance regulating these processes. There was no reason to suspect that morphine would bind to pain receptors in the brain until enkephalines were discovered, it can thus be surmised that endogenous molecules exist who are mimicked by the substances tested in our experiments. They would present interesting cosmetic (and pharmacological?) potential.