Role for Presupplementary Motor Area in Inhibition of Cognitive Set Interference

摘要

Proactive interference (PI), which is formed through repetitionnof certain behavior and lasts for a while, needs to be inhibitednin order for subsequent behavior to prevail over the antecedentnone. Although the inhibitory mechanisms in the pFC have beennreported that are recruited long after one behavior is updated tonanother, very little is known about the inhibitorymechanisms thatnare recruited immediately after the update. The WCST was modifiednin the present fMRI study such that inhibition of PI could benexamined both immediately after and long after update of behavior.nUse of “dual-match” stimuli allowed us to compare two typesnof trials where inhibition of PI was and was not required (controlnand release trials, respectively). Significant activation was observednin the left pre-SMA during control versus release trials.nThe pre-SMA activation was selective to PI inhibition requirednimmediately after update of behavior, which exhibited markedncontrast to the left anterior prefrontal activation selective to PIninhibition required long after the update. These results revealndissociable inhibitory mechanisms in these two regions that arenrecruited in the different temporal contexts of the inhibitory demandsnimposed during performance of the task. ■