Association between TNF-αpromoter polymorphism and Helicobacter pylori cagA subtype infection

摘要

Aims-To assess the importance of tumour necrosis factor α (TNF-α) pro- moter polymorphism in relation to infec- tion with the cytotoxin associated gene A (cagA) subtype of Helicobacter pylori within a dyspeptic Korean population. Methods-Eighty three patients with gas- Tric disease and 113 healthy controls were Studied. The DNA from gastric biopsy Specimens was analysed by H pylori spe- Cific and cagA specific polymerase chain Reaction (PCR). To characterse TNF-α Polymorphism at positions-308 and -238, PCR based restriction fragment length Polymorphism analysis was performed.