p53 codon 72 polymorphims and human papillomavirus assoicated skin cancer

摘要

Background/Aims-Non-melanoma skin cancers frequently harbour multiple human papillomavirus (HPV) types. A recent report suggests that a polymor- phims of the p53 tumour suppressor gene that results in the substitution of a proline residue with an arginine residue at posi- tion 72 of th ep53 protein might act as a risk factor in HPV associated malig- nancies. This study aimed to determine the following: (1) the relation between HPV infection and the development of Cutaneous squamous cell arcinoma (SCC), and (2) whether there is a correla- tion between p53 codon 72 polymorphism and the development of SCC.