Downregulation of transforming growth factor β type II receptor in laryngeal carcinogenesis

摘要

Aims-To investigate whether anomalies of transforming growth factor β type II receptor (TGF-β RII) expression occur in the early stages of laryngeal carcinogen- esis and to assess their importance in the development of laryngeal squamous cell carcinoma. TGF-β RII status was exam- ined in laryngeal premalignant lesions coupled with malignant evolution and compared with a control group of similar lesions without progression to cancer.