Sarcomatoid renal cell carcinoma is an example of epithelial—mesenchymal transition

摘要

Background Sarcomatoid renal cell carcinomas (SRCC) are composed of two cell populations, a sarcomatous component (SC) and a carcinomatous component (CC). SRCC are particularly aggressive and often present at an advanced stage at diagnosis. Epithelial—mesenchymal transition (EMT) has been proposed as a mechanism for the development of SC from CC.