Synthesis of 1-Methylethyl 2-Chloro-5[[5,6-dihydro-2-methyl-1, 4- oxathiin-3-yl) carbonyl] amino] Benzoate Analogs and Their Antiviral Activity

摘要

1-Methylethyl 2-chloro-5-[[5,6-dihydro-2-methyl-1, 4-oxathiin-3-yl] carbonyl] amino] benzoate (UC84) has strong antiviral activity. UC84 was taken as the leading compound and 11 analogs were synthesized. All these compounds were evaluated and some of them showed the obvious anti-HBV and anti-HSV activities. The re- sults indicated that the analogs of 1-methylethyl 2-chloro-5-[[5,6-dihykdro-2-methkyl-1, 4-oxathiin-3-yl]carbonyl] amino] benzoate (UC84) might be the potential anti-HSV and anit-HBV drugs.