Nucleosides XIII. Facile Synthesis of 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazolin-2-one as a 2′-Deoxycytidine Analog for Oligonucleotide Synthesis

Tun-Cheng Chien; Chien-Shu Chen; Ji-Wang Chern

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Nucleosides XIII. Facile Synthesis of 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazolin-2-one as a 2′-Deoxycytidine Analog for Oligonucleotide Synthesis

机译：核苷XIII。轻松合成4-氨基-1-（2-脱氧-β-D-呋喃呋喃糖基）喹唑啉-2-一，作为2'-脱氧胞苷类似物的寡核苷酸合成

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摘要

4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazolin-2-one (4) was prepared by Barton deoxygenation from 4-amino-1-(β-D-ribofuranosyl)quinazolin-2-one (3) as a 2′-deoxycytidine analog.

机译：通过Barton脱氧从4-氨基-1-（β-D-呋喃呋喃糖基）喹唑啉-2-酮（ 3）作为2'-脱氧胞苷类似物。

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来源
《Journal of the Chinese Chemical Society》 |2005年第6期|p.1237-1244|共8页
作者
Tun-Cheng Chien; Chien-Shu Chen; Ji-Wang Chern;
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作者单位

Division of Medicinal Chemistry, College of Pharmacy, The University of Texas at Austin, Austin, TX 78712, USA;

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原文格式 PDF
正文语种 eng
中图分类化学;化学工业;
关键词
2′-deoxycytidine; cytidine; quinazolinone; barton deoxygenation; markiewicz silylation;

机译：2'-脱氧胞苷;胞苷;喹唑啉酮;巴顿脱氧;Markiewicz甲硅烷基化;

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专利

1. Nucleosides XIII. Facile Synthesis of 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazolin-2-one as a 2′-Deoxycytidine Analog for Oligonucleotide Synthesis [J] . Tun-Cheng Chien, Chien-Shu Chen, Ji-Wang Chern Journal of the Chinese Chemical Society. . 2005,第6期

机译：核苷XIII。轻松合成4-氨基-1-（2-脱氧-β-D-呋喃呋喃糖基）喹唑啉-2-一，作为2'-脱氧胞苷类似物，用于寡核苷酸合成
2. A new synthesis of certain 7-(β-D-ribofuranosyl) and 7-{2-deoxy-β-D-ribofuranosyl) derivatives of 3-deazaguanine via the sodium salt glycosylation procedure [J] . Ganapathi R. Revankar, Pranab K. Gupta, Roland K. Robins Nucleic acids research . 1985,第14期

机译：通过钠盐糖基化法合成3-脱氮鸟嘌呤的某些7-（β-D-呋喃核糖基）和7- {2-脱氧-β-D-呋喃核糖基）衍生物
3. Synthesis of antisense oligonucleotides containing acyclic alkynyl nucleoside analogs and their biophysical and biological properties [J] . Ogata Aya, Maeda Yusuke, Ueno Yoshihito Bioorganic and medicinal chemistry . 2017,第7期

机译：含环丙基炔基核苷类似物及其生物物理和生物学性质的反义寡核苷酸的合成
4. Facile Synthesis of Na, Nε-(O-Nucleoside O-Alkyl Phosphoryl)Lysine Methyl Esters [C] . Bo Han International symposium for Chinese organic chemists . 2000

机译：Na，Nε-（O-核苷O-烷基磷酰基磷酰基磷酸酯的合成
5. Part I: Synthesis of Cyclobutyl Nucleoside Analogs That Mimic AZT for Inhibition of the K65R HIV-1 Reverse Transcriptase Mutant. Part II: Synthesis and Evaluation of Truncated Triptolide Analogs to Suppress Chronic Inflammation [D] . Bluemling, Gregory Richard 2011

机译：第一部分：模拟AZT抑制K65R HIV-1逆转录酶突变体的环丁基核苷类似物的合成。第二部分：截短雷公藤甲素类似物的合成和评估，以抑制慢性炎症
6. Facile Solid-Phase Synthesis and Assessment of Nucleoside Analogs as Inhibitors of Bacterial UDP-Sugar Processing Enzymes [O] . Amaël G. E. Madec, Nathaniel S. Schocker, Silvano Sanchini, -1

机译：方便的固相合成和核苷类似物作为细菌UDP-糖加工酶抑制剂的评估
7. Nucleosides. CXLVIII. : Synthesis of 6-(β-D-Ribofuranosyl)picolinamide. : A Novel C-Nucleoside from D-Ribonolactone [O] . MAREK M. KABAT, KRZYSZTOF W. PANKIEWICZ, ELZBIETA SOCHACKA, 1988

机译：核苷。 cxlviii。：合成6-（β-D-核呋喃糖基）吡啶胺。：来自D-核糖酮的新型C-核苷

Nucleosides XIII. Facile Synthesis of 4-Amino-1-(2-deoxy-β-D-ribofuranosyl)quinazolin-2-one as a 2′-Deoxycytidine Analog for Oligonucleotide Synthesis

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