Electrocatalytic Reduction of Metronidazole on Bismuth Modified Pencil-lead Electrode

摘要

We report a new and simple approach based on an experimental design method for the preparation of pencil-lead electrode modified with bismuth thin film. The fabrication process consists of reduction of bismuth on the surface of electrode with potentiostate method. Response surface methodology was developed as experimental strategies for modeling and optimization of the influence of some variables on the performance of modified electrode. The electrocatalytic behavior of this modified electrode was exploited as a sensitive detection system for the mercury-free reduction and determination of metronidazole in pharmaceutical and biological samples by using differential pulse voltammetry and amperometry methods.