Facile One-pot Synthesis of Substituted Dihydropyrrol-2-ones via Four-component Domino Reaction of Amines, Dialkyl Acetylenedicarboxylates and Formaldehyde

摘要

A mild and efficient method for the one-pot synthesis of substituted dihydropyrrol-2-one derivatives is described via four-component domino reaction of amines, dialkyl acetylenedicarboxyaltes and formaldehyde in the presence of 1-methyl-2-oxopyrrolidinium hydrogen sulfate ([Hpyro][HSO_4]) as ionic liquid catalyst. This facile approach proceeded smoothly in good to high yields and pure products are separated from the reaction mixture by simple filtration.