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High serum HER2 extracellular domain levels: correlation with a worse disease-free survival and overall survival in primary operable breast cancer patients

机译：血清HER2高细胞外结构域水平：与原发性可手术乳腺癌患者无病生存率和总生存率差相关

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摘要

High serum human epidermal growth factors receptor-2 (HER2) extracellular domain (ECD) has been identified as an independent prognostic indicator of poor prognosis in metastatic breast cancer. However, its prognostic value in primary operable breast cancer was still controversial. We aim to investigate the correlation between serum HER2 ECD levels and tissue HER2 status, the association between serum HER2 ECD levels and clinicopathological characteristics, and their impacts on disease-free survival (DFS) and overall survival (OS) in primary operable breast cancer.
机译：高血清人表皮生长因子受体2（HER2）细胞外域（ECD）已被确定为转移性乳腺癌预后不良的独立预后指标。然而，其在原发性可手术乳腺癌中的预后价值仍存在争议。我们旨在研究血清HER2 ECD水平与组织HER2状态之间的相关性，血清HER2 ECD水平与临床病理特征之间的关联，以及它们对原发性可手术乳腺癌中无病生存期（DFS）和总体生存期（OS）的影响。

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  • 来源
    《Journal of Cancer Research and Clinical Oncology》 |2012年第2期|p.275-284|共10页
  • 作者

    Yanan Kong; Shuqin Dai; Xinhua Xie; Xiangsheng Xiao; Ning Lv; Jiaoli Guo; Laisheng Li; Weihua Jia; Yin Zhang; Wanli Liu; Weidong Wei; Xiaoming Xie;

  • 作者单位

    State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China;

    State Key Laboratory of Oncology in South China, Sun Yat-Sen University Cancer Center, Guangzhou, Guangdong, 510060, People’s Republic of China;

    State Key Laboratory of Oncology;

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  • 原文格式 PDF
  • 正文语种 eng
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  • 关键词

    Serum HER2 ECD; Prognosis; Primary operable breast cancer;

    机译：血清HER2 ECD;预后;原发性可手术性乳腺癌;

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