Bioresorption of porous three-dimensional chi-tosan-based materials intended for use in medical surgical cosmetology and tissue engi-neering

摘要

Three-dimensional matrices with high porosity were prepared by lyophilization of chitosan solution. The mechanism and rate of resorption of the resulting materials were studied in vivo. It was shown that resorption was completed in 12 months after implantation into an animal. The formation of connective tissue was not observed and the surrounding tissue had no signs of changes or damage. Histological analysis demonstrates that chitosan resorption occurred simultaneously with the formation of collagen fibers and blood vessels. These results allow us to recommend the obtained chitosan- based porous material for use as a matrix for tissue engineering and medical cosmetology.