Skin Lightening Efficacy of New Formulations Enhanced by Chitin Nanoparticles Delivery System. Note Ⅰ

摘要

This preliminary study reports the whitening efficacy obtained in vivo by the contemporary topical use of 3 cosmetic emulsions enriched with the designed nanoparticles and applied for a period of 6 months on the skin of 40 voluntary subjects, female and male, affected by hyperpigmentation in different skin areas. Before the skin treatment, different Chitin Nanofibril-Hyaluronan (CN-HA) block copolymeric nanoparticles, entrapping known whitening agents, were controlled in vitro to verify their activity on the melanogenetic process. It was controlled in vitro their antioxidant and anti-inflammatory activity together with the possibility to interfere on melanin synthesis and melanosome transfer. From the obtained results it has been shown that the combined activity of different whitening agents entrapped into natural nanoparticles as carrier, gives as result an interesting depigmenting effectiveness without any side effect. A new study is in progress to confirm these data.