Chemoenzymatic Synthesis of 11-cis-Retinal Photoaffinity Analog by Use of Squid Retinochrome

摘要

In conclusion, photoisomerization of all-trans-retinal analogs to the 11-cis isomer with retinochrome can be utilized as an efficient synthetic method. This is because the 11-cis geometry is established at the last stage of synthesis with high stereose- lective output; moreover, it is applicable to radioactive analogs containing, e.g., tritium, which would be essential for sequencing the cross-linked sites.