A Novel Biphasic Bone Scaffold: β-Calcium Phosphate and Amorphous Calcium Polyphosphate

摘要

Calcium polyphosphate (CPP) was added to hydroxyapa-tite (HA) to develop a novel biphasic calcium phosphate (BCP). The effects of varying CPP dosage on the sintering property, the mechanical strength, and the phase compositions of HA were investigated. Results showed that CPP reacted with HA and produced β-calcium phosphate (β-TCP) and H_2O and that an excessive dosage of CPP ( > 10 wt%) obtained a novel BCP of β-TCP/amorphous-CPP, while a lesser dosage of CPP (<10 wt%) obtained a traditional BCP (HA/β-TCP). The porous β-TCP/amorphous-CPP scaffolds (porosity of 66.7%, pore diameter of 150-450 μm, and compressive strength of 6.70 ± 1.5 Mpa) were fabricated and then: in vitro degradation results showed a significant improvement of degradation with the addition of CPP.