Novel trichloroindolizine derivatives via intramolecular acylation of a bis(chloroacyl)bipyridine

摘要

3,3u0001-Bis(alkyloxycarbonyl)-2,2u0001-bipyridines are produced from the reaction of alcohols with 3,3u0001-bis(chlorocarbonyl)-n2,2u0001-bipyridine which is generated from the corresponding dicarboxylic acid and thionyl chloride. When thendicarboxylic acid is reacted with a SOCl2–Cl2 mixture, significant amounts of trichloroindolizines are produced.nThis reaction is likely to take place via initial intramolecular N-chloroacylation of bipyridine 3.