Comparative Cell-Mediated Immunogenicity of DNA/DNA, DNA/Adenovirus Type 5 (Ad5), or Ad5/Ad5 HIV-1 Clade B gag Vaccine Prime-Boost Regimens

David M. Asmuth; Elizabeth L. Brown; Mark J. DiNubile; Xiao Sun; Carlos del Rio; Clayton Harro; Michael C. Keefer; James G. Kublin; Sheri A. Dubey; Lisa S. Kierstead; Danilo R. Casimiro; John W. Shiver; Michael N. Robertson; Erin K. Quirk

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Comparative Cell-Mediated Immunogenicity of DNA/DNA, DNA/Adenovirus Type 5 (Ad5), or Ad5/Ad5 HIV-1 Clade B gag Vaccine Prime-Boost Regimens

机译：DNA / DNA，DNA / 5型腺病毒（Ad5）或Ad5 / Ad5 HIV-1 Clade B gag疫苗初免疗法的细胞介导的免疫原性比较

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BackgroundWe report composite results from the Merck phase I program of near-consensus clade B human immunodeficiency virus (HIV) type 1 gag vaccines

机译：背景我们报告了默克进化枝B型人类免疫缺陷病毒（HIV）1型gag疫苗的默克I期计划的综合结果

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《Journal of Infectious Diseases》 |2010年第1期|p.132-141|共10页
作者
David M. Asmuth; Elizabeth L. Brown; Mark J. DiNubile; Xiao Sun; Carlos del Rio; Clayton Harro; Michael C. Keefer; James G. Kublin; Sheri A. Dubey; Lisa S. Kierstead; Danilo R. Casimiro; John W. Shiver; Michael N. Robertson; Erin K. Quirk;
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Division of Infectious Disease, Department of Internal Medicine, University of California at Davis, Sacramento;

Merck Research Laboratories, West Point, Pennsylvania;

Merck Research Laboratories, West Point, Pennsylvania;

Merck Research Laboratories, West Point, Pennsylvania;

Hope Clinic, Emory University Vaccine Center, Decatur, Georgia;

Johns Hopkins Bloomberg School of Public Health, Baltimore, Maryland;

University of Rochester School of Medicine, Rochester, New York;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

Merck Research Laboratories, West Point, Pennsylvania;

Merck Research Laboratories, West Point, Pennsylvania;

Merck Research Laboratories, West Point, Pennsylvania;

Merck Research Laboratories, West Point, Pennsylvania;

Merck Research Laboratories, West Point, Pennsylvania;

Merck Research Laboratories, West Point, Pennsylvania;

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1. Comparative cell-mediated immunogenicity of DNA/DNA, DNA/adenovirus type 5 (Ad5), or Ad5/Ad5 HIV-1 clade B gag vaccine prime-boost regimens. [J] . Asmuth DM, Brown EL, DiNubile M The Journal of Infectious Diseases . 2010,第1期

机译：DNA / DNA，DNA / 5型腺病毒（Ad5）或Ad5 / Ad5 HIV-1进化枝B gag疫苗初免-加强疗法的细胞介导免疫原性比较。
2. Novel Adenovirus type 5 vaccine platform induces cellular immunity against HIV-1 Gag, Pol, Nef despite the presence of Ad5 immunity. (Special Issue: Advances in vaccine technology II 2008.) [J] . Gabitzsch E. S., Xu Y. N., Yoshida L. H., Vaccine . 2009,第46期

机译：尽管存在Ad5免疫，新型5型腺病毒疫苗平台仍可诱导针对HIV-1 Gag，Pol，Nef的细胞免疫。（特刊：疫苗技术的进步II，2008年。）
3. Improved SIV DNA vaccine can be effectively used as a boost for Ad5 in prime-boost immunization strategy [J] . BelyakovI.M. Expert review of vaccines . 2012,第7期

机译：改良的SIV DNA疫苗可以有效地用作初免-加强免疫策略中Ad5的增强剂
4. DNA Vaccines Co-expressing Containing Hsp70 and GP5/M Protein of Porcine Reproductive and Respiratory Syndrome Virus (PRRSV) Display Enhanced Immunogenicity [C] . Zuo Lan, Yan Qi-Gui, Lei Yan, International Conference on Mechanical Engineering and Intelligent Systems . 2012

机译：DNA疫苗共同含有HSP70和猪生殖和呼吸综合征病毒（PRRSV）的GP5 / M蛋白显示出增强的免疫原性
5. Expression and immunogenicity of DNA vaccines containing the env and gag-pol genes of equine infectious anemia virus. [D] . Zhou, Weisong. 2001

机译：包含马传染性贫血病毒的env和gag-pol基因的DNA疫苗的表达和免疫原性。
6. DNA gag/Adenovirus Type 5 (Ad5) gag and Ad5 gag/Ad5 gag Vaccines Induce Distinct T-Cell Response Profiles [O] . Kara S. Cox, James H. Clair, Michael T. Prokop, 2008

机译：DNA gag /腺病毒5型（ad5）gag和Ad5 gag / Ad5 gag疫苗可诱导不同的T细胞反应谱
7. Comparative Cell‐Mediated Immunogenicity of DNA/DNA, DNA/Adenovirus Type 5 (Ad5), or Ad5/Ad5 HIV‐1 Clade BgagVaccine Prime‐Boost Regimens [O] . David M. Asmuth, Elizabeth L. Brown, Mark J. DiNubile, 2010

机译：比较细胞介导的DNA / DNA的免疫原性，DNA /腺病毒型5（AD5），或AD5 / AD5 HIV-1 CLADE BGVAGCAGINE Prime-Boost方案

Comparative Cell-Mediated Immunogenicity of DNA/DNA, DNA/Adenovirus Type 5 (Ad5), or Ad5/Ad5 HIV-1 Clade B gag Vaccine Prime-Boost Regimens

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