A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers

Paul Spearman; Michelle A. Lally; Marnie Elizaga; David Montefiori; Georgia D. Tomaras; M. Juliana McElrath; John Hural; Stephen C. De Rosa; Alicia Sato; Yunda Huang; Sharon E. Frey; Paul Sato; John Donnelly; Susan Barnett; Lawrence J. Corey

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A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers

机译：三聚体，V2缺失的HIV-1包膜糖蛋白疫苗可激发有效的中和抗体，但在人类志愿者中中和的范围有限。

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Background. A key missing element in the development of a successful human immunodeficiency virus (HIV) vaccine is an immunogen that can generate broadly cross-neutralizing antibodies against primary isolates of the virus.

机译：背景。成功的人类免疫缺陷病毒（HIV）疫苗开发中的一个关键缺失要素是一种免疫原，可以产生针对该病毒主要分离株的广泛交叉中和抗体。

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《Journal of Infectious Diseases》 |2011年第8期|p.1165-1173|共9页
作者
Paul Spearman; Michelle A. Lally; Marnie Elizaga; David Montefiori; Georgia D. Tomaras; M. Juliana McElrath; John Hural; Stephen C. De Rosa; Alicia Sato; Yunda Huang; Sharon E. Frey; Paul Sato; John Donnelly; Susan Barnett; Lawrence J. Corey;
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Department of Pediatrics, Emory University and Children's Healthcare of Atlanta, Georgia;

Department of Medicine, Miriam Hospital and Alpert Medical School of Brown University, Providence, Rhode Island;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

Department of Surgery, Duke University School of Medicine, Durham, North Carolina;

Department of Surgery, Duke University School of Medicine, Durham, North Carolina;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

Department of Internal Medicine, St. Louis University School of Medicine, Missouri;

Division of AIDS, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, Maryland;

Novartis Vaccines and Diagnostics, Cambridge, Massachusetts;

Novartis Vaccines and Diagnostics, Cambridge, Massachusetts;

Fred Hutchinson Cancer Research Center, Seattle, Washington;

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1. A trimeric, V2-deleted HIV-1 envelope glycoprotein vaccine elicits potent neutralizing antibodies but limited breadth of neutralization in human volunteers. [J] . Spearman P, Lally MA, Elizaga M, The Journal of Infectious Diseases . 2011,第8期

机译：一种三聚体，缺失V2的HIV-1包膜糖蛋白疫苗可引发有效的中和抗体，但在人类志愿者中产生的中和范围有限。
2. Analysis of the neutralizing antibody response elicited in rabbits by repeated inoculation with trimeric HIV-1 envelope glycoproteins [J] . Grundner C, Li YX, Louder M, Virology . 2005,第1期

机译：重复接种三聚体HIV-1包膜糖蛋白对兔引起的中和抗体反应的分析
3. Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies. [J] . Choudhry V, Zhang MY, Sidorov IA, Virology . 2007,第1期

机译：交叉反应性HIV-1中和性单克隆抗体，可通过筛选针对人包膜糖蛋白（gp140）的免疫人噬菌体文库进行筛选，该包膜糖蛋白从具有广泛HIV-1中性抗体的患者（R2）中分离。
4. A Bispecific Multivalent HIV-1 Neutralizing Antibody Potently Suppresses SHIV Infection [C] . You Li, Yanling Wu, Dimiter S. Dimitrov, Protein Engineering Summit. . 2018

机译：双特异性多价HIV-1中和抗体效果抑制了SHIV感染
5. Selection and Analysis of HIV-1 Envelope Epitopes for Design of Vaccines that can Induce Broadly Neutralizing Antibodies [D] . Wieczorek, Lindsay 2012

机译：HIV-1包膜抗原决定簇的选择和分析，用于设计可诱导广泛中和抗体的疫苗
6. A Trimeric V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers [O] . Paul Spearman, Michelle A. Lally, Marnie Elizaga, -1

机译：三聚体V2缺失的HIV-1包膜糖蛋白疫苗可激发有效的中和抗体但在人类志愿者中中和的范围有限。
7. A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers [O] . Spearman, Paul, Lally, Michelle A., Elizaga, Marnie, 2011

机译：三聚体，V2缺失的HIV-1包膜糖蛋白疫苗可激发有效的中和抗体，但在人类志愿者中中和的范围有限。

A Trimeric, V2-Deleted HIV-1 Envelope Glycoprotein Vaccine Elicits Potent Neutralizing Antibodies but Limited Breadth of Neutralization in Human Volunteers

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