Development of motion resistant instrumentation for ambulatory near-infrared spectroscopy

摘要

Ambulatory near-infrared spectroscopy (aNIRS) enables recording of systemic or tissue-specific hemodynamicsnand oxygenation during a person’s normal activities. It has particular potential for the diagnosis andnmanagement of health problems with unpredictable and transient hemodynamic symptoms, or medical conditionsnrequiring continuous, long-duration monitoring. aNIRS is also needed in conditions where regular monitoring ornimaging cannot be applied, including remote environments such as during spaceflight or at high altitude. One keynto the successful application of aNIRS is reducing the impact of motion artifacts in aNIRS recordings. In this paper,nwe describe the development of a novel prototype aNIRS monitor, called NINscan, and our efforts to reducenmotion artifacts in aNIRS monitoring. Powered by 2 AA size batteries and weighting 350 g, NINscan recordsnNIRS, ECG, respiration, and acceleration for up to 14 h at a 250 Hz sampling rate. The system’s performancenand resistance to motion is demonstrated by long term quantitative phantom tests, Valsalva maneuver tests, andnmultiparameter monitoring during parabolic flight and high altitude hiking. To the best of our knowledge, this isnthe first report of multiparameter aNIRS monitoring and its application in parabolic flight.