Iris as a reflector for differential absorption low-coherence interferometry to measure glucose level in the anterior chamber

摘要

Abstract. We present a method of glucose concentration detection in the anterior chamber with a differentialnabsorption optical low-coherent interferometry (LCI) technique. Back-reflected light from the iris, passing throughnthe anterior chamber twice, was selectively obtained with the LCI technique. Two light sources, one centerednwithin (1625 nm) and the other centered outside (1310 nm) of a glucose absorption band were used for differentialnabsorption measurement. In the eye model and pig eye experiments, we obtained a resolution glucose level ofn26.8 mg/dL and 69.6 mg/dL, respectively. This method has a potential application for noninvasive detection ofnglucose concentration in aqueous humor, which is related to the glucose concentration in blood. C u00022011 Society ofnPhoto-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.3528658]