BOUND RESIDUES OF ~(14)C-CARBOFURAN AND ~(14)C-MALATHION IN STORED SOYBEAN SEEDS AND THEIR TOXICOLOGICAL EFFECTS ON MICE

摘要

Soybeans treated with ~(14)C-carbofuran or ~(14)C-malathion at a dose of 30 mg/kg and stored for 30 weeks showed that the organophosphorus insecticide malathion had a higher binding tendency to soybean seeds than the carbamate insecticide carbofuran. The amount of malathion bound ~(14)C-residues were almost three times higher (as percentage of applied dose) than carbofuran bound residues. Sub-chronic feeding experiments on mice for 90 days with a diet containing the bound ~(14)C-residues at a dose of 0.91 and 2.39 ppm/day/mouse for carbofuran and malathion, respectively, caused non-significant symptoms of toxicity during the period of the experiment. A slight inhibition in plasma and erythrocyte choline esterase activities was observed during the second and third months in both treated mice fed on carbofuran or malathion. Liver enzymes, total protein, albumin, cholesterol, triglycerides and kidney functions showed non-significant differences from control values in case of mice fed on ~(14)C-bound carbofuran residues. However, these mentioned blood parameters showed only slight increase, as compared with controls, in treated mice fed on ~(14)C-bound malathion residues.