Influence of NFκB inhibitors on IL-1β-induced chemokine CXCL8 and -10 expression levels in intestinal epithelial cell lines: glucocorticoid ineffectiveness and paradoxical effect of PDTC

摘要

Purpose Activation of intestinal epithelial cell (IEC) nuclear factor κB (NFκB) and the consequent chemokine upregulation are crucial events in inflammatory bowel disease (IBD) pathogenesis. Not much is known about the consequences of NFκB inhibition in terms of chemokine expression in intestinal cells. Therefore, we aimed to evaluate the efficacy of compounds known to disrupt the NFκB pathway on NFκB transcriptional activity and CXCL8 and CXCL10 gene expression in intestinal cell lines.