Grafting of 2-Hydroxypropyl-β-Cyclodextrin on Gum Arabic-Modified Iron Oxide Nanoparticles as a Magnetic Carrier for Targeted Delivery of Hydrophobic Anticancer Drug

摘要

A new magnetic nanocarrier for the targeted delivery of hydrophobic drugs was developed by modifying magnetic nanoparticles with gum arabic and grafting with 2-hydroxypropyl-cyclodextrins (HCD) using hexamethylene diisocyanate (HMDI) as a linker. The size, hydrodynamic diameter, and grafting of HCD were characterized. The resultant magnetic nanocarrier exhibited an excellent capability to load all-trans-retinoic acid (ATRA), an anticancer agent. The better biocom-patibility and the combined properties of specific targeting and complexation ability with hydrophobic drugs make the nano-system an exciting prospect for targeted delivery of hydrophobic drugs.