Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile

Huan Yang; Yong Zhang; Minghua Wu; Jing Li; Wenbin Zhou; Guiyuan Li; Xiaoling Li; Bo Xiao; Premkumar Christadoss

首页> 外文期刊>Inflammation Research >Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile

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Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile

机译：RelB沉默的骨髓树突状细胞转移抑制正在进行的实验性自身免疫性重症肌无力与从T辅助Th17 / Th1到Th2和FoxP3 + 调节性T细胞谱的改变有关

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Objective To observe the therapeutic effect of RelB-silenced dendritic cells (DCs) in experimental autoimmune myasthenia gravis (EAMG), and further to investigate the mechanism of this immune system therapeutic.

机译：目的观察RelB沉默的树突状细胞（DCs）在实验性自身免疫性重症肌无力（EAMG）中的治疗效果，并进一步研究这种免疫系统的治疗机制。

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来源
《Inflammation Research》 |2010年第3期|p.197-205|共9页
作者
Huan Yang; Yong Zhang; Minghua Wu; Jing Li; Wenbin Zhou; Guiyuan Li; Xiaoling Li; Bo Xiao; Premkumar Christadoss;
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正文语种 eng
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关键词
Dendritic cells; RelB; Experimental myasthenia gravis; T; cell profile;

机译：树突状细胞;RelB;实验性重症肌无力;T;小区资料;

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1. Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile. [J] . Yang H, Zhang Y, Wu M, Inflammation research: Official journal of the European Histamine Research Society . 2010,第3期

机译：通过转移RelB沉默的骨髓树突状细胞来抑制正在进行的实验性自身免疫性重症肌无力与从T辅助Th17 / Th1到Th2和FoxP3 +调节性T细胞谱的改变有关。
2. Administration of bone marrow stromal cells ameliorates experimental autoimmune myasthenia gravis by altering the balance of Th1/Th2/Th17/Treg cell subsets through the secretion of TGF-beta. [J] . Kong QF, Sun B, Bai SS Journal of Neuroimmunology: Official Bulletin of the Research Committee on Neuroimmunology of the World Federation of Neurology . 2009,第1a2期

机译：骨髓基质细胞的给药可通过分泌TGF-β改变Th1 / Th2 / Th17 / Treg细胞亚群的平衡来改善实验性自身免疫性重症肌无力。
3. Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC [J] . Chandan Verma, Jennifer M Eremin, Adrian Robins, Journal of Translational Medicine . 2013,第1期

机译：在患有大型和局部晚期乳腺癌的女性中，T型调节细胞（Tregs：FoxP3 +，CTLA-4 +），骨髓衍生的抑制细胞（MDSC：单核细胞：单核细胞，粒细胞）和偏振的T辅助细胞谱（Th1，Th2，Th17） Neoadjuvant化疗（NAC）和手术：废除异常Treg曲线的失败，治疗和Treg水平与NAC病理反应的相关性
4. Abnormal T regulatory cells (Tregs: FOXP3+ CTLA-4+) myeloid-derived suppressor cells (MDSCs: monocytic granulocytic) and polarised T helper cell profiles (Th1 Th2 Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC [O] . Chandan Verma, Jennifer M Eremin, Adrian Robins, 2013

机译：患有大型和局部晚期乳腺癌的女性T调节细胞异常（Tregs：FOXP3 +CTLA-4 +）髓样来源的抑制细胞（MDSCs：单核细胞粒细胞）和极化的T辅助细胞谱（Th1Th2Th17）新辅助化疗（NAC）和手术：治疗无效的treg谱废除失败以及treg水平与NAC病理反应的相关性
5. Abnormal T regulatory cells (Tregs: FOXP3+, CTLA-4+), myeloid-derived suppressor cells (MDSCs: Monocytic, granulocytic) and polarised T helper cell profiles (Th1, Th2, Th17) in women with large and locally advanced breast cancers undergoing neoadjuvant chemotherapy (NAC) and surgery: failure of abolition of abnormal treg profile with treatment and correlation of treg levels with pathological response to NAC [O] . Verma, C., Eremin, J. M., Robins, A., 2013

机译：患有大型和局部晚期乳腺癌的女性，T调节细胞异常（Tregs：FOXP3 +，CTLA-4 +），髓样来源的抑制细胞（MDSCs：单核细胞，粒细胞）和极化的T辅助细胞特征（Th1，Th2，Th17）新辅助化疗（NAC）和手术：治疗无效treg谱的消除失败以及treg水平与NAC病理反应的相关性

Suppression of ongoing experimental autoimmune myasthenia gravis by transfer of RelB-silenced bone marrow dentritic cells is associated with a change from a T helper Th17/Th1 to a Th2 and FoxP3+ regulatory T-cell profile

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