Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats

Tao Yang; Junjie Zhang; Lulu Sun; Xiaoyan Zhu; Jinbao Li; Jiafeng Wang; Hui Chen; Rui Bao; Xiaoming Deng; Jiong Hou; Yujian Liu

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Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats

机译：中性粒细胞弹性蛋白酶抑制剂（双降司他钠）和自由基清除剂（依达拉奉）对脂多糖诱导的大鼠急性肺损伤的联合作用

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摘要

The present study aimed to investigate the combined effects of a neutrophil elastase inhibitor, sivelestat sodium, with a free radical scavenger, edaravone, on lipolysaccharide (LPS)-induced acute lung injury (ALI).

机译：本研究旨在研究中性粒细胞弹性蛋白酶抑制剂sivelestat钠与自由基清除剂依达拉奉对脂多糖（LPS）诱导的急性肺损伤（ALI）的联合作用。

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来源
《Inflammation Research》 |2012年第6期|p.563-569|共7页
作者
Tao Yang; Junjie Zhang; Lulu Sun; Xiaoyan Zhu; Jinbao Li; Jiafeng Wang; Hui Chen; Rui Bao; Xiaoming Deng; Jiong Hou; Yujian Liu;
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作者单位

Department of Anesthesiology, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, People’s Republic of China;

Departments of Obstetrics and Gynecology, Changhai Hospital, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, People’s Republic of China;

Department of Anesthesiology, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, People’s Republic of China;

Department of Physiology, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, People’s Republic of China;

Department of Anesthesiology, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, People’s Republic of China;

Department of Anesthesiology, Second Military Medical University, 800 Xiangyin Road, 200433, Shanghai, People’s Republic of China;

Department of Anesthesiology, Second Military Medical University, 800 Xiangyin Road, 2004;

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正文语种 eng
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关键词
Lipopolysaccharide; Acute lung injury; Neutrophil elastase; Oxidative stress;

机译：脂多糖;急性肺损伤;中性粒细胞弹性蛋白酶;氧化应激;

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1. Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats. [J] . Tao Yang, Junjie Zhang, Lulu Sun, Inflammation research: Official journal of the European Histamine Research Society . 2012,第6期

机译：中性粒细胞弹性蛋白酶抑制剂（依格司他钠）和自由基清除剂（依达拉奉）对脂多糖诱导的大鼠急性肺损伤的联合作用。
2. Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) in the Treatment of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS): A Systematic Review and Meta-Analysis [J] . Kentaro Iwata, Asako Doi, Goh Ohji, Internal medicine. . 2011,第22期

机译：中性粒细胞弹性蛋白酶抑制剂（Sivelestat钠）在治疗急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）中的作用：系统评价和荟萃分析
3. Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) in the Treatment of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS): A Systematic Review and Meta-Analysis [J] . Kentaro Iwata, Asako Doi, Goh Ohji, Internal medicine. . 2010,第22期

机译：中性粒细胞弹性蛋白酶抑制剂（Sivelestat钠）在治疗急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）中的作用：系统评价和荟萃分析
4. The effects of a free radical scavenger, edaravone,combined with mild hypothermia on ischemic brain damage following transient middle cerebral artery occlusion in rats [C] . Chikako Nito, Tatsushi Kamiya, Shimon Amemiya, International Symposium on Molecular Mechanism and Epochal Therapeutics for Ischemic Stroke and Dementia . 2003

机译：自由基清除剂，依达拉夫酮与轻度体温过低的效果对大鼠瞬时中脑动脉闭塞后缺血性脑损伤
5. Role of angiostatin in neutrophil biology and acute lung injury. [D] . Aulakh, Gurpreet Kaur. 2011

机译：血管抑素在中性粒细胞生物学和急性肺损伤中的作用。
6. Usefulness of a selective neutrophil elastase inhibitor sivelestat in acute lung injury patients with sepsis [O] . Seigo Miyoshi, Hironobu Hamada, Ryoji Ito, 2013

机译：选择性中性粒细胞弹性蛋白酶抑制剂sivelestat在脓毒症急性肺损伤患者中的用途
7. Effect of Neutrophil Elastase Inhibitor (Sivelestat Sodium) in the Treatment of Acute Lung Injury (ALI) and Acute Respiratory Distress Syndrome (ARDS): A Systematic Review and Meta-Analysis [O] . Kentaro Iwata, Asako Doi, Goh Ohji, 2010

机译：中性粒细胞弹性蛋白酶抑制剂（Sivelestat钠）治疗急性肺损伤（ALI）和急性呼吸窘迫综合征（ARDS）的影响：系统审查和荟萃分析
8. Effects of Ammonium Nitrate Aerosol Exposure on Lung Structure of Normal and Elastase-Impaired Rats and Guinea Pigs [R] . Busch, R. H., Buschbom, R. L., Cannon, W. C., 1986

机译：硝酸铵气溶胶暴露对正常和弹性蛋白酶受损大鼠和豚鼠肺组织的影响

Combined effects of a neutrophil elastase inhibitor (sivelestat sodium) and a free radical scavenger (edaravone) on lipopolysaccharide-induced acute lung injury in rats

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