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Neuroinformatics as a megascience issue

机译:神经信息学作为大科学问题

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摘要

The greatest increment in acquired knowledge about the brain has occurred in the last two decades, aided by technological advances in molecular biology, molecular genetics, brain imaging, and other new technologies brought about through the computer revolution. The amount of information being generated is increasing in an exponential fashion due to these and ether approaches used by the estimated 50000 neuroscientists working around the globe. These individual investigators working in small groups on highly focused projects publish their results in one of the roughly 200 scientific journals which are published monthly. It is humanly impossible under the current system to integrate all of these data into a meaningful picture of how the brain develops and functions and malfunctions. The complexity and quantity of neuroscience data drives the need to create a global information management system for the neuroscience community. The possibility to do this has already been amply demonstrated by the genome community through bioinformatics. Compared to sequence data, data generated through neuroscience research have many more levels of complexity, including genomic data. This effective demonstration in bioinformatics and the continual advances in the fields of computer and information sciences clearly point to the need for the neuroscience community to embrace and engage the science of informatics, through the global development of the new field of neuroinformatics.
机译:在过去的二十年中,得益于分子生物学,分子遗传学,脑成像以及计算机革命带来的其他新技术的发展,获得的有关大脑的知识有了最大的增长。估计的信息量正以指数方式增长,这是由于全球估计有5万名神经科学家使用了这些方法和以太方法。这些个人研究人员以小组的形式致力于高度专注的项目,其结果在每月出版的大约200种科学期刊之一中发表。在当前系统下,人类不可能将所有这些数据整合到大脑如何发育,功能和故障的有意义的画面中。神经科学数据的复杂性和数量推动了为神经科学界创建全球信息管理系统的需求。基因组界已通过生物信息学充分证明了这样做的可能性。与序列数据相比,通过神经科学研究产生的数据具有更高的复杂度,包括基因组数据。生物信息学的这一有效展示以及计算机和信息科学领域的不断进步,明确表明神经科学界需要通过神经信息学新领域的全球发展来拥抱和参与信息科学。

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