Part 1: Network biology in translational bioinformatics and systems biology

摘要

Identifying driver mutations as well as disease genes that are responsible for various disorders is the key to understand the molecular mechanisms underlying diseases in translational bioinformatics. At the same time, the knowledge about drug targets can help design compounds with better efficacy. Recently, the availability of various types of molecular networks makes it possible to identify disease genes or drug targets from systematic perspectives. In this special issue, we reported the recent progress on computational approaches that have been developed to predict disease genes and drug targets.